隐孢子虫感染小鼠MHC-Ⅱ类抗原的表达
秦元华;郑莉莉;戴晓冬;任一鑫;崔昱
【期刊名称】《中国人兽共患病学报》 【年(卷),期】2011(027)003
【摘要】To observe the treating function of Fructus Psoraleae and dihydroartemisinin on mouse infected with Cryptosporidiurn parvum and to research the regulating function of major histocompatibility complex- Ⅱ , 60 mice were randomly divided into five groups: normal group A; positive control group- Ⅰ B;one-week treatment group C; positive control group- Ⅱ D; two-week treatment group E. Mice in group B, C, D, and E were injected subcutaneously with dexamethasone. When the mice were infected with C. parvum, they were treated with the medicine respectively. The intestine tissue was observed via HE.The expression of MHC-Ⅱ were observed by immunohistochemistry. The damaged intestine got improved and repaired, and a significant decrease of the amount of C. parvum oocysts in feces was shown in the treated groups (C, E) compared with positive control groups (B, D) (P＜0. 05). In 1-week treatment group, the MHC- Ⅱ expression of group B was higher than that of normal group A. There was no difference between the expression of MHC- Ⅱ in group B and that in group C; in 2-week treatment group, there was no difference between the expression of MHC- Ⅱ in group E and that in group A. The MHC- Ⅱ expression of
隐孢子虫感染小鼠MHC-Ⅱ类抗原的表达
