Protective Effects of Resveratrol and its Analogues against Free Radical-Induced Oxidative

Protective Effects of Resveratrol and its Analogues against Free Radical-Induced Oxidative Hemolysis

of Red Blood Cells

FANG,Jian-Guo(房建国);LU,Man(陆曼);MA,Lan-Ping(马兰萍);YANG,Li(杨立);WU,Long-Min(吴隆民);LIU,Zhong-Li(刘中立)

【期刊名称】《中国化学（英文版）》 【年(卷),期】2002(020)011

【摘要】The in vitro oxidative hemolysis of human red blood cells ( RBCs) was used as a model to study the free radical-induced damage of biological membranes and the protective effect of resveratroi (3,5,4′-trihydroxy-trans-stilbene, 1) and its analogues, i. e., 4-hydroxy-trans-stilbene(2), 3, 5-dihydroxytrans-stilbene (3), 3,4-dihydroxy-trans-stilbene (4), 4,4′-dihydroxy-trans-stilbene (5) and 2, 4, 4′-trihydroxy-trans-stilbene (6). The hemolysis of RBCs was induced by a water-soluble free radical initiator 2, 2′-azobis ( 2-amidinopropane hydrochloride) (AAPH). It was found that addition of AAPH at 37 ℃ to the suspension of RBCs caused fast hemolysis after a short period of inhibition period, and addition of 1-6 significantly suppressed the hemolysis. Compound 4 which bears an ortho-dihydroxyl functionality showed nuch more effective anti-hemolysis activity than that of resveratrol and the other analogues. 【总页数】6页(1313-1318)