左西孟旦对心搏骤停-心肺复苏后大鼠心功能的保护作用

左西孟旦对心搏骤停-心肺复苏后大鼠心功能的保护作用

郭建;杨正飞;凌钦;杨倩;陆晓晔;朱长清

【期刊名称】《临床急诊杂志》 【年(卷),期】2017(018)012

【摘要】Objective:To study the protective effects of levosimendan in post resuscitation rat cardiac function by establishing a rat cardiac arrest

and

resuscitation

model

with

the

help

of

echocardiography.Method:Twenty-nine healthy male SD rats were randomly divided into sham group (n=5),LEVO group (n=12) and control group (n =12).We established cardiac arrest model in control and LEVO groups.After 6 minutes untreated cardiac arrest,cardio-pulmonary resuscitation was given.We observed 6 hours.The LEVO group was treated with levosimendan during and after CPR,while the control and sham group were given equivalent volume of saline solution.The sham group was not induced into cardiac arrest,no resuscitation as well.They were used to offer baseline data for our study,together with LEVO and control group,gas analysis and echocardiography data were recorded per hour after resuscitation at 1～6 h.Result:Eleven rats were successfully resuscitated in LEVO group (91.7％),9 rats were successfully resuscitated in control group,there was no significant differences in success rate of resuscitation (P=0.590).All resuscitated rats have survived 6 hours.The cardiac function has