Antibacterial Properties of a Kind of Schiff Base and Its Neodymium(Ⅲ)and Zn(Ⅱ)Complex

Antibacterial Properties of a Kind of Schiff Base

and Its Neodymium(Ⅲ)and

Zn(Ⅱ)Complex(ZnNdL)on Escherichia coli

LI Chaohong;ZHU Juncheng;QI Zude;HOU Hanna;HU Yanjun;LIU Yi

【期刊名称】《中国化学（英文版）》 【年(卷),期】2009(027)009

【摘要】The microcalorimetric and electronic microscopy methods were used to study the antibacterial activity of a Schiff base and its complex ZnNdL on Escherichia coil The metabolic power-time curves of the bacteria treated with the compounds were obtained,and the thermokinetic parameters were analyzed.The results show that the compounds(H2L,ZnNdL)have good activity on aerobic multiplying metabolism of E.coli,with the values of IC50 tronic microscopy and scanning electronic micrography were used to study the cell membrane change induced by the dibasic quadridentate Schiff base and its neodymium(Ⅲ)complex.At a low concentration of the compound,the flagellum was inhibited and the cell did not show distinct changes.However,the flagella around the cell membrane were exfoliated,the morphology of E.coli was changed from a rod shape into a spherical shape or a short rod,and the flagella disappeared completely at a high concentration.The drug permeability into cell membrane was investigated by fluorescence quenching of probe dis-C3-(5),which

suggested that H2L and ZnNdL could influence on the intra and extra cell membrane.

【总页数】6页(1657-1662) 【关键词】

【作者】LI Chaohong;ZHU Juncheng;QI Zude;HOU Hanna;HU Yanjun;LIU Yi

【作者单位】Wuhan

University;Wuhan

University;Wuhan

University;Wuhan University;Wuhan University;Wuhan University 【正文语种】中文 【中图分类】 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_chinese-journal-chemistry_thesis/0201251283510.html 【相关文献】

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