左眶额皮质低频重复经颅磁刺激治疗强迫症的初步研究
米丝;杨祥云;周丹娜;王玉娟;任艳萍;李占江
【期刊名称】《中华精神科杂志》 【年(卷),期】2018(051)006
【摘要】Objective To primarily explore the efficacy,onset time and safety of low frequency repetitive transcranial magnetic stimulation (rTMS) over the left orbitofrontal cortex (LOFC) on obsessive-compulsive disorder(OCD).Methods Twenty-four OCD patients were randomly assigned into 2 groups,one group (n＝12) with sertraline and rTMS,the other group (n＝12) with sertraline and sham rTMS.The stimulus parameter was 80～-110～ motor threshold,1 Hz,5 sessions per week.The efficacy was assessed by using Y-BOCS,HAMD and HAMA at base line,2,4 and 6th week after treatment,and the safety by recording Adverse Event and Severe Adverse Event.Results The scores of Y-BOCS(F＝23.401,P＜0.01),obsession(F＝23.516,P＜0.01),compulsion (F＝15.025,P＜0.01),HAMD (F＝7.23,P＜0.01) and HAMA (F＝8.389,P＝0.002) of 2 groups all significantly decreased after 6 week treatment,but there was no significant differences between 2 groups.The effective rate of the two groups was statictically different (Fisher test,P＝0.030),and the remission rate was not statistically different (Fisher test,P＝0.183).The Y-BOCS scores in the sertraline + rTMS group at 2 week treatment (23.0 ± 5.1 vs.18.1 ± 5.7) were statistically different from the baseline(LSD test,P
左眶额皮质低频重复经颅磁刺激治疗强迫症的初步研究
