Interactions Between Effects of Estrogen Receptor Gene Polymorphisms on BMD and Experience

Interactions Between Effects of Estrogen Receptor Gene Polymorphisms on BMD and Experiences of

the First Spermorrhea in Chinese Han Boys

JING YIN; QIAN ZHANG; XIAO-QI HU; WEI-JING DU; AI-LING LIU; XIAO-YAN WANG; ZHI-QIN TONG; GUAN-SHENG MA

【期刊名称】《《生物医学与环境科学（英文版）》》 【年(卷),期】2008(021)002

【摘要】Objective To study the interaction between polymorphisms of estrogen

receptor(ER)gene

and

puberty

on

bone

mineral

density(BMD).Methods One hundred and forty-six boys aGEd 13-17 years were divided into two groups according to their first spermorrhea.DNA wag analyzed for Xba I and Pvu Ⅱ genotypes by PCR-RFLE BMD of the total body,forearm and lumbar spine was measured by dual-energy X-ray absorptiome TRY(DXA).The relationship between polymorphisms of ER gene and BMD in these two groups was analyzed. Results The BMD at all sites in the spermorrhea group was significantly higher than that in the un-spermorrhea group.The independent contribution of ER genotypes to BMD at two pubertal stages was analyzed after adjusting co-variables.In the un-spermorrhea group,the BMD at distal 1/10 and 1/3 forearm of those carrying PP genotype was significantly higher than that of the non-carries,whereas in the spermorrhea group BMD in those carrying the same genotype

was significantly lower than that in the non-carriers.Similar results were obtained by haplotype analysis.Multiple stepwise regression analysis showed that body weight,age and the first spermorrehea were the dominant determinants for BMD.BMD at forearm might be influenced by

interaction

between

ER

genotype

and

the

first

spermorrehea.Conclusion The polymorphisms of ER gene play a different role in BMD influenced by the first spermorrhea.Chinese boys carrying Porx allele should pay more attention to their bone mass. 【总页数】8页(129-136)

【关键词】BMD; Puberty; Hormones and receptors; Polymorphism; Boys 【作者】JING YIN; QIAN ZHANG; XIAO-QI HU; WEI-JING DU; AI-LING LIU; XIAO-YAN WANG; ZHI-QIN TONG; GUAN-SHENG MA

【作者单位】National Institute for Nutrition and Food Safety Chinese Center for Disease Control and Prevention 29NanweiRoad Beijing 1000050 China 【正文语种】中文 【中图分类】R3 【文献来源】

https://www.zhangqiaokeyan.com/academic-journal-cn_biomedical-environmental-sciences_thesis/0201275152488.html 【相关文献】 1.Interactions

Between

Effects

of

Estrogen

Receptor

Gene

Polymorphisms on BMD and Experiences of the First Spermorrhea in Chinese Han Boys [J], JING YIN; QIAN ZHANG; XIAO-QI HU; WEI-JING DU; AI-LING LIU; XIAO-YAN WANG; ZHI-QIN TONG; GUAN-SHENG MA

2.Interaction effects between estrogen receptor α and vitamin D receptor genes on age at menarche in Chinese women [J], Hong XU; Ji-rong LONG; Miao-xin LI; Hong-wen DENG

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4.Association of peroxisome proliferator-activated receptor single-nucleotide polymorphisms and gene-gene interactions with the lipoprotein(a) [J], 解惠坚

5.Association of vitamin D receptor and estrogen receptor-α gene polymorphism with peak bone mass and bone size in Chinese women [J], Yue-juan QIN; Zhen-lin ZHANG; Qi-ren HUANG; Jin-wei HE; Yun-qiu HU; Qi ZHOU; Jing-hui LU; Miao LI; Yu-juan LIU

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