花青素对动脉粥样硬化模型小鼠抗氧化和血脂代谢的影响
欧海龙;张庆海
【期刊名称】《中国当代医药》 【年(卷),期】2015(000)022
【摘要】Objective To explore the effect of cyanidine on antioxidant capacity and lipids metabolism in arterioscle-rosis mode mice. Methods After ApoE-/-mice were given high fat diet for 8 weeks,they were intragastric administrated different dose of cyanidine (low,media and high:50,100 and 200 mg/kg respectively) for continuous 8 weeks.Serum and livers of the mice were acquired and various index of antioxidant and levels of lipids were tested. Results At media and high dose,the improved activation of SOD in serum and the decreased levels of MDA in serum and livers had signifi-cant difference compared with control group(P<0.05).The activation of SOD in livers had significant difference(P<0.05). Various index of lipids such as TC,TG and LDL-C decreased with the increase of dose.TG in media and high dose had significant difference,while TC and LDL-C in high dose had significant difference compared with control group (P<0.05). Conclusion Cyanidine has the functions of antioxidant and decreasing lipids in high fat diet-inducedarterioscle-rosis mice.%目的：探讨花青素在动脉粥样硬化模型小鼠体内抗氧化能力和血脂代谢中的作用。方法高脂饮食诱导基因敲除的ApoE-/-小鼠8周后，每天用不同剂量(低、中、高院50、100、200 mg/kg)的花青素
花青素对动脉粥样硬化模型小鼠抗氧化和血脂代谢的影响
