Synthesis, Characterization and Biological Activity of Diorganotin(IV) Complexes of N-(3,5

Synthesis, Characterization and Biological Activity

of Diorganotin(IV) Complexes of N-(3,5-Dibromosalicylidene)-a-amino Acid

TIAN Lai-Jin; SUN Yu-xi; ZHENG Xiao-Liang; LIU Xi-Jie; YU You; LIU Xue-Li; QIAN Bo-Chu

【期刊名称】《《中国化学（英文版）》》 【年(卷),期】2007(025)003

【摘要】The diorganotin(Ⅳ) complexes of N-(3,5-dibromosalicylidene)-a-amino acid, R2Sn(2-O-3,5-Br2C6H2CH=NCHRCOO)(where R=H, Me, i-Pr, Bz; R'=n-Bu, Cy), were synthesized by the reactions of diorganotin dichlorides with in situ formed potassium salt of N-(3,5-dibromosalicylidene)-a-amino acid and characterized by elemental analysis, IR and NMR (1H, 13C and 119Sn) spectra. The crystal structures of n-Bu2Sn(2-O-3,5-Br2C6H2CH=NCHRCOO)(R= i-Pr, Bz) and Cy2Sn(2-O-3,5-Br2C6H2CH=NCHRCOO)(R=Me, Bz) were determined by X-ray single crystal diffraction and showed that the tin atoms are in a distorted trigonal bipyramidal geometry to form five- and six-membered chelate rings with the tridentate ligand. Bioassay results indicated that the compounds possess better in vitro antitumour activity against three human tumour cell lines, HeLa, CoLo205 and MCF-7, than cis-platin and moderate anti-bacterial activity against two bacteria, E. coli and S. aureus.