癌胚抗原相关细胞黏附分子6检测诊断胆管癌

癌胚抗原相关细胞黏附分子6检测诊断胆管癌

王文斌;刘兵;武海波;何伟;王天阳

【期刊名称】《中华实验外科杂志》 【年(卷),期】2017(034)012

【摘要】目的 探讨特定肿瘤标志物癌胚抗原相关细胞黏附分子6(CEACAM6)对胆管癌的诊断价值.方法 收集胆管癌患者70例和胆管炎对照者15例,采用酶联免疫吸附试验法(ELISA)测定各组患者血清CEACAM6水平,根据受试者工作特征(ROC)曲线中敏感性和特异性之和最高点为参考,制定CEACAM6的截点值并计算ROC曲线下面积,根据肿瘤标志物诊断效率评估表评价各个肿瘤标志物对胆管癌诊断效率.结果 在胆管癌癌患者中,CEACAM6的血清值和阳性率[(0.189±0.134) ng/ml和84％]与胆管炎组比较显著升高[(0.109±0.023) ng/ml和37％;t=3.238,P=0.016];根据ROC曲线,CEACAM6在本次实验中血清中含量测定的截点值为0.185 1 ng/ml,CEACAM6、糖类抗原19-9(CA19-9)、癌胚抗原(CEA)曲线下面积分别为0.835、0.870、0.828,95％可信区间(cI)分别为0.758～0.912、0.803～0.936、0.749～0.906.胆管癌诊断敏感性CEACAM6＞CA19-9＞ CEA(t=2.046,P=0.012);特异性CA19-9＞ CEACAM6＞ CEA(t=1.833,P=0.001).结论 CEACAM6与CA19-9联合检测有助于胆管癌早期诊断.%Objective To investigate the diagnostic value of serum carcinoembryonic antigenelated cell adhesion molecule 6 (CEACAM6) for

cholangiocarcinoma.Methods

Seventy

patients

with

cholangiocarcinoma and 15 with cholangitis were examined for serum levels of CEACAM6 by enzyme linked immunosorbent assay (ELISA).The