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实验与检验医学2024年8月第37卷第4期ExperimentalandLaboratoryMedicine,Aug.2024,Vol.37,No.4
·实验研究·
多参数流式细胞术对急性髓系白血病微小残留病变的监测及对患者复发率的影响
王升，张琰，武永强
(安阳地区医院袁河南安阳455000)
摘要:目的探究多参数流式细胞术对急性髓系白血病微小残留病变的监测及对患者复发率的影响遥方法回顾性分析我院在2015年6月-2017年7月期间采用多参数流式细胞术监测白血病微小残留渊MRD冤治疗急性髓系白血病患者作为本次的研究对象袁观察比较患者治疗前后生活质量水平袁并且分析治疗前急性髓系白血病患者的相关免疫的表型渊LAIP冤袁同时对治疗后的微小残留病变的水平进行检测遥结果治疗后急性髓系白血病患者在认知功能尧躯体功能以及角色功能和社会功能等方面的生活质量水平明显优于治疗前渊P<0.05冤曰130例初发的急性髓系白血病患者的免疫表型分析袁有120例具有明确的LAIP袁有18例具有单一的LAIP类型袁有112例具有2个或者2个以上的LAIP类型曰50例进行诱导化疗并且达到完全缓解且2个疗程的巩固治疗的急性髓系白血病患者的MBD检测结果为袁27例检测诱导MRD(Post-IndMRD+)中袁有20例患者复发袁23例Post-IndMRD-中袁有8例复发袁Post-IndMRD+和Post-IndMRD-患者的平均无病生存时间差异具有统计学意义ConsMRD-患者的平均无病生存时间差异具有统计学意义渊P<0.05冤遥结论Post-IndMRD和Post-ConsMRD与患者的平均渊P<0.05冤袁22例巩固治疗后MRD渊Post-ConsMRD+全部复发袁28例Post-ConsMRD-有6例复发袁Post-ConsMRD+和Post-
无病生存时间有关袁且多参数流式细胞术监测患者MRD并干预治疗袁可以有效的降低急性髓系白血病微小残留病变的复发率遥
关键词：多参数流式细胞术曰急性髓系白血病曰微小残留病变曰患者复发率DOI院10.3969/j.issn.1674-1129.2024.04.012中图分类号：R446.11+3袁R551
文献标识码：A
文章编号：1674-1129(2024)04-0598-04
MonitoringofminimalresiduallesionsinacutemyeloidleukemiabymultiparameterflowcytometryanditseffectontherecurrencerateofpatientsWANGSheng1袁ZHANGDan2袁WUYongqiang3.AnyangDistrictHospitalofHenanprovince455000.
Abstract院ObjectiveToinvestigatetheeffectofmultiparameterflowcytometryonthedetectionofminimalresiduallesionsin
acutemyeloidleukemia(AML)andtherecurrencerate.MethodsAretrospectiveanalysiswasmadeonthemonitoringofminimalresidualleukemia(MRD)bymulti-parameterflowcytometryinpatientswithacutemyeloidleukemiainourhospitalfromJunepatientswithacutemyeloidleukemiabeforeandaftertreatmentwasanalyzed.LAIPandthelevelofminimalresiduallesionsafter2015toJuly2017.Thelifequalityofpatientsbeforeandaftertreatmentwasobservedandcompared袁andtherelatedimmunityof
thanthatbeforetreatmentintermsofcognitivefunction袁physicalfunction袁rolefunctionandsocialfunction(P<0.05).130casesofsingleLAIPtype袁112caseswith2ormorethan2typesofLAIP曰consolidatethetreatmentof50casesofacutemyeloidinductionacutemyeloidleukemiapatientswithprimaryimmunephenotypeanalysis袁120caseswithclearLAIP袁therewere18caseswithchemotherapyandachievedcompleteremissionand2coursesoftheDepartmentofleukemiapatientswithMBDresults袁27casesPost-ConsMRD+Post-ConsMRD-in28casesofrecurrence袁6casesofrecurrence袁Post-ConsTheaveragedisease-freesurvivalducetherecurrencerateofminimalresidualdiseaseinacutemyeloidleukemia.
treatmentweredetected.ResultsThelifequalityofpatientswithacutemyeloidleukemiaaftertreatmentwassignificantlybetter
ofPost-IndMRD+袁therewere20patientswithrecurrence袁23casesofPost-IndMRD-袁8casesofrecurrence袁MRD+andPost-timeofMRD+andPost-ConsMRD-patientswasstatisticallysignificant(P<0.05).ConclusionPost-IndMRDandPost-Cons
Keywords:Multiparameterflowcytometry曰Acutemyeloidleukemia曰Minimalresidualdisease曰Recurrencerateofpatients
IndPost-IndinpatientswithMRD-averagedisease-freesurvivaltimedifferencewasstatisticallysignificant(P<0.05)袁22casesofMRDwereassociatedwiththeaveragediseasefreesurvivaltimeofpatients袁andmultiparameterflowcytometrycaneffectivelyre鄄
男，主要从事临床检验工作。作者简介：王升，1970年生，本科，副主任技师，
多参数流式细胞术对急性髓系白血病微小残留病变的监测及对患者复 - 论文
