Product Data?SheetPotassium oxonateCat. No.:CAS No.:分?式:分?量:作?靶点:作?通路:储存?式:HY-175112207-75-2C?H?KN?O?195.17OthersOthersPowderIn solvent-20°C4°C-80°C-20°C3 years2 years6 months1 monthInhibitors?Agonists?Screening Libraries溶解性数据体外实验H2O : 9.09 mg/mL (46.57 mM; Need ultrasonic)DMSO : < 1 mg/mL (insoluble or slightly soluble)Mass1 mg5 mg10 mgSolventConcentration制备储备液1 mM5 mM10 mM5.1237 mL1.0247 mL0.5124 mL25.6187 mL5.1237 mL2.5619 mL51.2374 mL10.2475 mL5.1237 mL请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；?旦配成溶液，请分装保存，避免反复冻融造成的产品失效。储备液的保存?式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个?内使?，-20°C 储存时，请在 1 个?内使?。体内实验请根据您的实验动物和给药?式选择适当的溶解?案。以下溶解?案都请先按照 In Vitro ?式配制澄清的储备液，再依次添加助溶剂： 为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的?作液，建议您现?现配，当天使?； 以下溶剂前显?的百分?是指该溶剂在您配制终溶液中的体积占?；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的?式助溶1. 请依序添加每种溶剂：?0.5% CMC-Na/saline waterSolubility: 25 mg/mL (128.09 mM); Suspended solution; Need ultrasonic and warmingBIOLOGICAL ACTIVITY?物活性Potassium oxonate 是尿酸酶抑制剂，能抑制5-FU磷酸化为5-fluorouridine-5'-monophosphate。Page 1 of 2 www.MedChemExpress.cn
REFERENCES
[1].?Shirasaka T, et al. Inhibition by oxonic acid of gastrointestinal toxicity of 5-fluorouracil without loss of its antitumor activity in rats. Cancer Res. 1993 Sep 1;53(17):4004-9.
[2].?Eraranta A, et al. Oxonic acid-induced hyperuricemia elevates plasma aldosterone in experimental renal insufficiency. J Hypertens. 2008 Aug;26(8):1661-8.
McePdfHeightCaution: Product has not been fully validated for medical applications. For research use only.
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Master of Small Molecules — 您?边的抑制剂?师
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氧嗪酸钾作用机制- Medchemexpress- MCE中国
